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Monday, April 3

Sure It's Alzheimer's? Insights into Lewy Body Dementia

VIDEO:

Lewy Body dementia is the 2nd most common form of dementia. See experts at Mayo Clinic improving the lives of people who struggle with it.


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  1. The Lewy Body Dementia Assn. webpage (LBDA.org) and the Lewy Body Rollercoaster both have a lot of good information about LBD. So does the book A Caregiver's Guide to Lewy Body Dementia.

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  2. About Dementia with Lewy Bodies(LDB),that looks to be a "mix" of Alzheimer and Parkinson,researchers could deeply study support therapy with the nutraceutical CARNOSINE,that is a heavy metal chelator,a peroxinitrites scavenger and anti-glycating agent,lowers betamyloid and alpha synuclein accumulations,and has synergistic effects with the nutraceutical Acetyl L Carnitine (ALCAR)that is a mitochondrial function improver, peroxinitrites scavenger , increases brain energy,lowers betamyloid and tau accumulation,etc.And CARNOSINE has the potential to lowers betamyloid accumulation in Alzheimer disease(1),lowers alpha-synuclein accumulation in Parkinson disease and in Dementia of Lewy Bodies(2),(3)and lowers the prion-like spreads(4)that happens inside the brain of AD,PD and DLB patients.Based in:1)Anti-aggregating Effect of the Naturally Occurring Dipeptide Carnosine on Betamyloid Fibril Formation 2013 PLoS);2)Antioxidative and Anti-inflammatory Protection From Carnosine in the Striatum of Treated Mice(2010,J Agric Food Chem.);3)Enhanced Oligomerization of the Alpha-Synuclein Mutant by the Copper,Zinc Superoxide Dismutase and Hydrogen Peroxide System"(2003,Molecules and Cells); 4)Zinc,Copper,and Carnosine Attenuate Neurotoxicity of Prion Fragment-Journal Metallomics 2011)(only in small doses under physician prescription).

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  3. Researchers could study deeply too,the nutraceuticalALC AR for research.Example:in safe and small doses of one hundred miligrams three to five times a day made in compounding pharmacies,under physician prescription,for studies in neurodegenerative diseases.ACETYL L CARNITINE,that has antidepressant and anxiolitic effects(1),is a peroxinitrites scavenger(2),improves mitochondrial function(3),increases brain energy in Parkinson disease(4),and has synergistic effects with middle-chain triglycerides(coconut oil)in mitochondrias(5),and,lowers betamyloid and tau,accumulation(6).

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    Replies
    1. Reference articles about ALCAR :
      1)"Mitochondrial Functions Modulate Neuroendocrine,Metabolic,Inflammatory,and Transcriptional Responses to Acute Psychological Stress"Proc Natl Acad Sci,2015
      2)"The Antioxidant Properties of Carnitine in Vitro,Cell Mol Biol Lett.2010 3)"Metabolomics Screening Identifies Reduced(levels of)L-Carnitine to be associated with Progressive Emphysema(Chronic Obstructive Pulmonary Disease)",J Clinical Science,2016
      4)"Clinical Pharmacodynamics of Acetyl-L-Carnitine in Patients with Parkinson's Disease"Int J Clin Pharmacol Res,1990 5)"Carnitine SupplementIon and Ketogenesis by Small-For-Date Neonates on Medium-and Long-Chain Fatty Acid Formulae,Biology of Neonate,2000
      6)"Acetyl-L-Carnitine Attenuates Homocysteine-Induced Alzheimer-Like Histopathological and Behavioral Abnormalities,Rejuvenation,2011

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